Newly-paroled former US Army ranger Cameron Poe is headed back to his wife, but must fly home aboard a prison transport flight dubbed "Jailbird" taking the “worst of the worst” prisoners, a group described as “pure predators”, to a new super-prison. Poe faces impossible odds when the transport plane is skyjacked mid-flight by the most vicious criminals in the country led by the mastermind — genius serial killer Cyrus "The Virus" Grissom, and backed by black militant Diamond Dog and psychopath Billy Bedlam.

Jane, a struggling but perpetually stoned actress, has a busy day ahead. She has several important tasks on her list, including buying more marijuana. Even though she already has a good start on the day's planned drug use, she eats her roommate's pot-laced cupcakes and embarks on a series of misadventures all over Los Angeles.